Lab member
Siro SIMIZU(Ph.D,Senior Research Scientist)
INTEREST OF MY RESEARCH
I am studying the mechanisms of tumor cell metastasis and of drug resistance. Nobel molecular targets of cancer chemotherapy are suggested by our results. The seeds of antitumor drug are searching using chemical array technology we have established.
EDUCATION
| 1989-1993 | Keio University, Department of Applied Chemistry |
| 1993-1998 | Graduate Course, Keio University, Faculty of Science and Technology |
DEGREES
| B.Sc. (1993) | Keio University |
| Dr. Engineering (1998) | Keio University |
APPOINTMENTS
| 1998-2000 | Special Postdoctoral Researcher, Antibiotics Laboratory, RIKEN |
| 2000-2007 | Research Scientist, Antibiotics Laboratory, RIKEN |
| 2007-present | Senior Research Scientist, Antibiotics Laboratory, RIKEN |
| 2009.Oct.- | Senior Research Scientist,Chemical Biology Core Facility, RIKEN ASI |
ACADEMIC ACTIVITIES
Oncology Research
MY HOBBY
Movies, Reading books
LIST OF SELECTED PUBLICATIONS
Takagi S., Simizu S., Osada, H.
RECK negatively regulates matrix metalloproteinase-9 transcription.
Cancer Res., 69, 1502-1508 (2009)Miyazaki I., Simizu S., Ichimiya H., Kawatani M., Osada, H.
Robust and systematic drug screening method using chemical arrays and the protein library: identification of novel inhibitors of carbonic anhydrase II.
Biosci. Biotechnol. Biochem., 72, 2739-2749 (2008)Simizu S., Suzuki T., Muroi M., Lai N. S., Takagi S., Dohmae N., Osada, H.
Involvement of disulfide bond formation in the activation of heparanase.
Cancer Res., 67, 7841-7849 (2007)Simizu S., Takagi S., Tamura Y., Osada, H.
RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines.
Cancer Res., 65, 7455-7461 (2005)Simizu, S., Osada, H.
Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines.
Nature Cell Biol., 2, 852-854 (2000)
 ORIGINAL PAPERS |
| < Prev | Next > |
|---|
