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Producing organism | Streptomyces pulveraceus subsp. epiderstagenes |
Biological activity | Mitogenic activity |
Abstract | A new glutarimide antibiotic named actiketal was isolated from the culture fluid of the epiderstatin-producing streptomycete, Streptomyces pulveraceus subsp. epiderstagenes. The IC50 of the antibiotic for inhibition of the incorporation of [3H]thymidine into epidermal growth factor-stimulated Balb/MK cells was 14.5 mM. The structure of this compound was determined by 1H and 13C NMR spectroscopic analyses using 1H-1H COSY, 13C-1H COSY, heteronuclear multiple-bond correlation spectroscopy, selective 13C-[1H] NOE's techniques |
References | isolation and structural determination |
| T. Sonoda, H. Osada, J. Uzawa, K. Isono Actiketal, a new member of the glutarimide antibiotics. J. Antibiotics 44, 160-163 (1991) ---->go to PubMed | |
| synthesis by other group | |
H. Kiyota, Y. Shimizu, T. Oritani |
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