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Cytoxazone

 


Producing organism

Streptomyces sp.

Biological activity

cytokine modulator

Abstract

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References

isolation and structural determination
 H. Kakeya, M. Morishita, K. Kobinata, M. Osono, M. Ishizuka, H. Osada
Isolation and biological activity of a novel cytokine modulator, cytoxazone.
J. Antibiotics 51, 1126-1128 (1998) ----> go to PubMed
 H. Kakeya, M. Morishita, H. Koshino, T. Morita, K. Kobayashi, H. Osada
Cytoxazone: A Novel Cytokine Modulator Containing a 2-Oxazolidinone Ring Produced by Streptomyces sp.
J. Org. Chem. 64, 1052-1053 (1999) ----> go to PubMed 
 synthesis by other group
 

Y. Sakamoto, A. Shiraishi, J. Seonhee, T. Nakata
Stereoselective syntheses of cytoxazone, a novel cytokine modulator, and its stereoisomers.
Tetrahedron Lett. 40, 4203-4206 (1999)

 P.H. Carter, J.R. LaPorte, P.A. Scherle, C.P. Decicco
A new synthesis of cytoxazone and its diastereomers provides key initial SAR information.
Bioorg. Med. Chem. Lett. 13, 1237-1239 (2003) ----> go to PubMed 

 

 

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