 |
Producing organism | Streptomyces platensis subsp. malvinus RK-1409 |
Biological activity | inhibitor of protein kinase C |
Abstract | A novel inhibitor of protein kinase C was found in the fermentation of a soil actinomycete, strain RK-1409. According to the taxonomic studies, the producing strain was designated as Streptomyces platensis subsp. malvinus RK-1409. The protein kinase C inhibitor, RK-1409 (7-oxostaurosporine) inhibited the morphological change of a human chronic erythroleukemia cell, K-562, induced by phorbol 12,13-dibutyrate (PDBu) at the concentration of 10 ng/ml. The concentration of 3 ng/ml inhibited the activity of protein kinase C in vitro. RK-1409 inhibited the cell cycle progression at G2 phase of K-562 cells. |
References | isolation and structural determination |
| H. Osada, H. Koshino, T. Kudo, R. Onose, K. Isono A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity. J. Antibiotics 45, 189-194 (1992) ----> go to PubMed | |
| H. Koshino, H. Osada, K. Isono A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties and structure. J. Antibiotics 45, 195-198 (1992) ----> go to PubMed | |
H. Koshino, H. Osada, S. Amano, R. Onose, K. Isono |
| < 前 | 次 > |
|---|
